MersV1, Main, Exploration, bibRecord, 004F81

Modified polynucleotides. V. Slow-down of nuclease action by 5-alkyluracil-containing DNAs

Identifieur interne : 004F81 ( Main/Exploration ); précédent : 004F80; suivant : 004F82

Modified polynucleotides. V. Slow-down of nuclease action by 5-alkyluracil-containing DNAs

Auteurs : J. Sági [Hongrie] ; L. Ötvös [Hongrie]

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1980.

RBID : ISTEX:29B8F9C0730728F1F914200A7F5FFECECCFBB243

English descriptors

KwdEn :
- bu or pe group which stand for hydrogen atom, et, ethyl, me, methyl, n-butyl, n-pentyl group, n-propyl, pr, respectively, two-letter symbols were used for 5-alkyl substitution of uracil in poly d/A-r5U/, where r was a h.
Teeft :
- Analogue, Biophysical research communications, Copolymer, Degradation, Dna, Dnase, Incubation figure, Micrococcal, Nuclease, Nucleic, Nucleic acids, Pancreatic, Pancreatic dnase, Phosphodiesterase, Poly, Polymer, Reaction mixture, Snake venom phosphodiesterase, Spleen dnase, Sqgi, Thymine, Venom.

Abstract

Abstract: Poly d/[3H]A-r5U/ type of synthetic models of bacteriophage DNAs containing thymine analogues were prepared by DNA polymerase and tested for stability against nucleases /r was a n-alkyl group from methyl to pentyl/. The 5-pentyluracil-containing copolymer was found to be most stable: 50 % degradation with pancreatic DNase, spleen DNase, snake venom phosphodiesterase or micrococcal nuclease required 3–15 times as much time as that of poly d/A-T/.

Url:

https://api.istex.fr/ark:/67375/6H6-L51T70B9-9/fulltext.pdf

DOI: 10.1016/0006-291X(80)90717-2

Affiliations:

Hongrie

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to stream Istex, to step Corpus: 000800
to stream Istex, to step Curation: 000800
to stream Istex, to step Checkpoint: 002432
to stream Main, to step Merge: 005061
to stream Main, to step Curation: 004F81

Le document en format XML

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<term>Dnase</term>
<term>Incubation figure</term>
<term>Micrococcal</term>
<term>Nuclease</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Pancreatic</term>
<term>Pancreatic dnase</term>
<term>Phosphodiesterase</term>
<term>Poly</term>
<term>Polymer</term>
<term>Reaction mixture</term>
<term>Snake venom phosphodiesterase</term>
<term>Spleen dnase</term>
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<front><div type="abstract" xml:lang="en">Abstract: Poly d/[3H]A-r5U/ type of synthetic models of bacteriophage DNAs containing thymine analogues were prepared by DNA polymerase and tested for stability against nucleases /r was a n-alkyl group from methyl to pentyl/. The 5-pentyluracil-containing copolymer was found to be most stable: 50 % degradation with pancreatic DNase, spleen DNase, snake venom phosphodiesterase or micrococcal nuclease required 3–15 times as much time as that of poly d/A-T/.</div>
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Modified polynucleotides. V. Slow-down of nuclease action by 5-alkyluracil-containing DNAs

Modified polynucleotides. V. Slow-down of nuclease action by 5-alkyluracil-containing DNAs

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri